Sterilization  is highly recommended in hospital and health care systems that which requires safety for patients and medical instrument which they are using. With COVID-19, it is a must in the all buildings that have higher human interaction like, company, organization, restaurant, and pharmacy. Even, homes now need to be Sterilized because we interact with others everyday. the Steam Sterilization method is found to be the best one since it is inexpensive, non-toxic and economic friendly.